We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

R.B. and E.V. acknowledge partial support from the Jump ARCHES (Applied Research through Community Health through Engineering and Simulation) endowment through the Health Care Engineering Systems ...

Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416–1421 (2022)].The ...

HBx plays a pivotal role in HBV replication by enhancing cccDNA transcription. However, the HBx structure remains unsolved, representing a significant gap in knowledge. Here, we show the cryo-EM ...

High-resistant starch (RS)/low-glutelin sbeIIb/Lgc1 lines were generated by CRISPR-Cas9-induced site-specific mutations in SBEIIb in an elite low-glutelin japonica rice cultivar ().According to this ...

Green pigmentation provides a wide variety of animals with the ability to camouflage themselves among green vegetation. The molecular mechanisms of green coloration in insects are not well-understood, ...

To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

Nav1.8 sodium channels are highly expressed in primary pain-sensing neurons. Suzetrigine is a potent and highly selective Nav1.8 inhibitor that has recently been approved by the Food and Drug ...

In this study, we utilized an emerging tubulogenesis model in the ascidian notochord (12, 29, 30), in which lumen pockets first appeared between pairs of notochord cells and then coalesced into a ...

Soft robotics hold immense potential in biomimetics and healthcare due to their exceptional flexibility, adaptability, and biocompatibility (1–3).The development of biomimetic soft robots often relies ...

This study was supported in part by Grants-in-Aid for Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KAKENHI Grant No. JP16H06452 to T.D.) ...

We thank the Heflin Genomics Institute at UAB, UAB fish facility staff, the University of Massachusetts Chan Medical School (UMass Chan) fish facility, the Research Computing teams at the University ...