We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416–1421 (2022)].The ...

High-resistant starch (RS)/low-glutelin sbeIIb/Lgc1 lines were generated by CRISPR-Cas9-induced site-specific mutations in SBEIIb in an elite low-glutelin japonica rice cultivar ().According to this ...

To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia ...

In this study, we utilized an emerging tubulogenesis model in the ascidian notochord (12, 29, 30), in which lumen pockets first appeared between pairs of notochord cells and then coalesced into a ...

Soft robotics hold immense potential in biomimetics and healthcare due to their exceptional flexibility, adaptability, and biocompatibility (1–3).The development of biomimetic soft robots often relies ...

We thank the Heflin Genomics Institute at UAB, UAB fish facility staff, the University of Massachusetts Chan Medical School (UMass Chan) fish facility, the Research Computing teams at the University ...

PNAS: Welcome to Science Sessions, the podcast of the Proceedings of the National Academy of Sciences, where we connect you with Academy members, researchers, and policymakers.Join us as we explore ...

The expansion of commodity agriculture is the leading driver of deforestation globally, which makes it crucial that we capture it accurately. Yet the way we monitor agricultural commodity frontiers ...

Animals that consume diets rich in fruits or other sources of simple carbohydrates have evolved mechanisms to neutralize and detoxify any accompanying ethanol produced by the natural fermentation ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...