Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

We recently discovered that the binding of mitochondrial precursor proteins to the ER surface is not simply the result of an unavoidable mislocalization, but rather that the ER-to-mitochondria ...

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Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

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Some studies have suggested that oligomerization of IRE1 is initiated by its ER-lumenal sensor domain (Credle et al, 2005; van Anken et al, 2014; Karagoz et al, 2017; Ricci et al, 2019; Belyy et al, ...

CIITA transcription itself is controlled by a 14 kb multi-promoter regulatory region, containing three independent promoter elements in humans, pI, pIII, and pIV, which are expressed in a ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

In this study, we generated new in-vivo treatment models of Brca1- and Bard1-mutant breast cancer that recapitulate the striking response to PARPi, acquired resistance, and recurrence that is observed ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...