Sperm morphogenesis is a tightly regulated differentiation process, disruption of which leads to sperm malfunction and male infertility. Here, we show that Tex38 knockout (KO) male mice are infertile.

Physical neural networks (PNN) using physical materials and devices to mimic synapses and neurons offer an energy-efficient way to implement artificial neural networks. Yet, training PNN is difficult ...

Peptide-based allosteric inhibitor targets TNFR1 conformationally active region and disables receptor–ligand signaling complex ...

The cGAS–STING pathway plays a key role in innate immunity by producing proinflammatory cytokines in response to cytosolic DNA. Moreover, activation of the pathway also leads to noncanonical autophagy ...

Antimicrobial resistance is a pressing global health challenge driven by human antibiotic consumption, among other factors. In this report, we investigate trends in human antibiotic consumption in 67 ...

We developed a strategy to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). To minimize confounders, we analyzed microbiota composition in a large cohort of ...

Birds are charismatic—well loved, and highly studied. Many new phylogenies elucidating avian evolutionary relationships are published every year. We have united phylogenetic estimates from hundreds of ...

Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target ...

Litter decomposition has profound implications for carbon fluxes and nutrient cycling, making it crucial to identify the key factors controlling decomposition rates for ecosystem management and ...

In this paper, we demonstrate that prolonged exertion of self-control via cognitively demanding tasks induces a state of fatigue marked by the emergence of sleep-like brain activity within the ...

A key question in biology is how tissue-wide coordination of cell polarity and growth shapes organ geometry (1 – 7), and how such regulation is modified during evolution to generate morphological ...

Antibodies are crucial in therapeutics and immune defense, but their hypervariable regions pose challenges for computational modeling. We introduce Antibody Mutagenesis-Augmented Processing (AbMAP), a ...