Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

We recently discovered that the binding of mitochondrial precursor proteins to the ER surface is not simply the result of an unavoidable mislocalization, but rather that the ER-to-mitochondria ...

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In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

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We demonstrate that TP53 deficiency in AML cells confers resistance to CAR T-cell therapy by inducing CAR T-cell dysfunction. We propose a model in which difficult-to-kill TP53-mutant AML cells ...

CIITA transcription itself is controlled by a 14 kb multi-promoter regulatory region, containing three independent promoter elements in humans, pI, pIII, and pIV, which are expressed in a ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

To overcome this challenge, cells use sterol products of the mevalonate pathway to negatively regulate its activity at two critical nodes. The first of these nodes is the sterol regulatory ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

ER–NE junctions were first visualized by electron microscopy more than 60 years ago in chemically fixed cells of rat spleen and maize root (Watson, 1955; Whaley et al, 1960).In these cells, the ER–NE ...